In chemical process operation, the purpose of control is to achieve optimal process
operation despite the presence of significant uncertainty about the plant behavior and …

In the 7 years after publishing the second edition of this book, both practical application as
well as theoretical research on preparative chromatography have progressed significantly …

Packed bed liquid chromatography is widely applied in academia and industry. Model-
based methods are increasingly utilized for process development and optimization …

To achieve a high level of purity in the purification of recombinant proteins for therapeutic or
analytical application, it is necessary to use several chromatographic steps. There is a range …

An iterative optimization strategy is proposed and applied to the set-point optimization of
batch chromatography in presence of a plant–model mismatch. As process-dependent …

Selecting optimum HPLC operating conditions during the development of new analytical
separations is difficult due to the high degree of process variable interaction and the lack of …

In this work, a new correlation for the axial dispersion coefficient was obtained using
experimental data in the literature for axial dispersion in fixed-bed columns packed with …

CADET is an open source modeling and simulation framework for column liquid
chromatography. The software is freely distributed to both academia and industry under the …

In this paper, we investigate the continuous production of high-fructose corn syrup in a
reactive simulated moving bed (RSMB) process which combines a quasi-continuous …

This work is focused on the transient analysis of the different mass transfer mechanisms
during the adsorption of metronidazole on activated carbon packed in a fixed-bed column …