Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Abnormal mechanical load is a main risk factor of intervertebral disc degeneration (IDD),
and cellular senescence is a pathological change in IDD. In addition, extracellular matrix …

With an aging population, there is a proportional increase in the prevalence of intervertebral
disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and …

Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic
and catabolic processes in the intervertebral disc, leading to an alteration in the composition …

The function of connective tissues depends on the physical and biochemical properties of
their extracellular matrix (ECM), which are in turn dictated by ECM protein composition. With …

Intervertebral disc degeneration (IDD) progresses due to local inflammatory response,
gradually unbalanced anabolic/catabolic activity, and progressive functional impairment …

Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

Musculoskeletal defects are an enormous healthcare burden and source of pain and
disability for individuals. With an aging population, the proportion of individuals living with …