X chromosome regulation represents a prime example of an epigenetic phenomenon where
coordinated regulation of a whole chromosome is required. In flies, this is achieved by …

The sex chromosomes have special significance in the history of genetics. The
chromosomal basis of inheritance was firmly established when Calvin Bridges demonstrated …

Confinement of the X chromosome to a territory for dosage compensation is a prime
example of how subnuclear compartmentalization is used to regulate transcription at the …

The Drosophila male-specific lethal (MSL) complex binds to the male X chromosome to
activate transcription. It comprises five proteins (MSL1, MSL2, MSL3, male absent on the first …

The rules defining which small fraction of related DNA sequences can be selectively bound
by a transcription factor are poorly understood. One of the most challenging tasks in DNA …

The MuvB complex recruits transcription factors to activate or repress genes with cell cycle-
dependent expression patterns. MuvB contains the DNA-binding protein LIN54, which …

Transcription regulators select their genomic binding sites from a large pool of similar, non-
functional sequences. Although general principles that allow such discrimination are known …

Dosage compensation is an essential process that equalizes transcript levels of X-linked
genes between sexes by forming a domain of coordinated gene expression. Throughout the …

Little is known about how variation in sequence composition alters transcription factor
occupancy to precisely recruit large transcription complexes. A key model for understanding …

Motivation In this article, we propose a method for finding similarities between Pfam families
based on the pre-trained neural network ProtENN2. We use the model ProtENN2 per …