The diverse functional roles of elongation factor Tu (EF-Tu) in microbial pathogenesis

KL Harvey, VM Jarocki, IG Charles… - Frontiers in …, 2019 - frontiersin.org
Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of
aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical …

Mycoplasma hyopneumoniae: from disease to vaccine development

S Simionatto, SB Marchioro, D Maes… - Veterinary …, 2013 - Elsevier
Mycoplasma hyopneumoniae is the etiological agent of swine enzootic pneumonia (EP), a
disease that affects swine production worldwide. Vaccination is the most cost-effective …

Elongation factor Tu is a multifunctional and processed moonlighting protein

M Widjaja, KL Harvey, L Hagemann, IJ Berry… - Scientific reports, 2017 - nature.com
Many bacterial moonlighting proteins were originally described in medically, agriculturally,
and commercially important members of the low G+ C Firmicutes. We show Elongation factor …

Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia

AT Deutscher, C Jenkins, FC Minion… - Molecular …, 2010 - Wiley Online Library
Mycoplasma hyopneumoniae, the causative agent of porcine enzootic pneumonia, adheres
to ciliated respiratory epithelia resulting in ciliostasis and epithelial cell death. The cilium …

Development and evaluation of recombinant B-Cell multi-epitopes of PDHA1 and GAPDH as subunit vaccines against Streptococcus iniae infection in flounder …

X Sheng, H Zhang, M Liu, X Tang, J Xing, H Chi… - Vaccines, 2023 - mdpi.com
Streptococcus iniae is a severe Gram-positive pathogen that can infect a wide range of
freshwater and marine fish species. In continuation of our earlier studies on the development …

Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates …

DR Bogema, AT Deutscher, LK Woolley, LM Seymour… - MBio, 2012 - Am Soc Microbiol
Mycoplasma hyopneumoniae causes enormous economic losses to swine production
worldwide by colonizing the ciliated epithelium in the porcine respiratory tract, resulting in …

Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain

W Liu, S Xiao, M Li, S Guo, S Li, R Luo, Z Feng, B Li… - BMC genomics, 2013 - Springer
Background Mycoplasma hyopneumoniae is the causative agent of porcine enzootic
pneumonia (EP), a mild, chronic pneumonia of swine. Despite presenting with low direct …

Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

J Wilton, C Jenkins, SJ Cordwell… - Molecular …, 2009 - Wiley Online Library
Mycoplasma hyopneumoniae induces respiratory disease in swine by colonizing cilia
causing ciliostasis, cilial loss and epithelial cell death. Heparin binds to M. hyopneumoniae …

Fructose-1,6-bisphosphate aldolase encoded by a core gene of Mycoplasma hyopneumoniae contributes to host cell adhesion

Y Yu, M Liu, L Hua, M Qiu, W Zhang, Y Wei, Y Gan… - Veterinary …, 2018 - Springer
Mycoplasma hyopneumoniae is an important respiratory pathogen that causes great
economic losses to the pig industry worldwide. Although some putative virulence factors …

Identification of Novel Immunogenic Proteins from Mycoplasma bovis and Establishment of an Indirect ELISA Based on Recombinant E1 Beta Subunit of the Pyruvate …

Z Sun, P Fu, K Wei, H Zhang, Y Zhang, J Xu, F Jiang… - PloS one, 2014 - journals.plos.org
The pathogen Mycoplasma bovis (M. bovis) is a major cause of respiratory disease, mastitis,
and arthritis in cattle. Screening the key immunogenic proteins and updating rapid …