Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer Disease (AD) is a neurodegenerative disease characterized by two
neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
worldwide. However, the complexity of AD pathogenesis leads to discrepancies in the …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Alzheimer's disease is one of at least 26 diseases characterized by tau-positive
accumulation in neurons, glia or both. However, it is still unclear what modifications cause …

Microglia are the cells that comprise the innate immune system in the brain. First described
more than a century ago, these cells were initially assigned a secondary role in the central …

Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative
diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in …

Tau protein (MAPT) is classified as a microtubule-associated protein (MAP) and is believed
to regulate the axonal microtubule arrangement. It belongs to the tau/MAP2/MAP4 family of …

Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …