Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

S Kumar, J Li, J Park, SK Hart, NJ Song, DT Burrow… - bioRxiv, 2020 - biorxiv.org
Chloroquine is an anti-malarial and immunosuppressant drug that has cationic amphipathic
chemical properties. We performed genome-wide screens in human cells with chloroquine …

Analyzing the Interconnectedness of the Human Genome

N Jacobs - 2022 - search.proquest.com
The human genome is much more interconnected than many people realize. In this thesis, I
will outline two efforts to portray this idea. First, I will seek to display that cell fitness is an …

Cell fitness is an omniphenotype

NC Jacobs, J Park, NL Saccone, TR Peterson - bioRxiv, 2018 - biorxiv.org
Moore's law states that computers get faster and less expensive over time. In contrast in
biopharma, there is the reverse spelling, Eroom's law, which states that drug discovery is …