Checkmate: Metabolic flexibility with a STING in its tail | Science Advances news careers
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Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …

Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune
responses to tumours and viral infection. However, in certain chronic diseases, including …

Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …

T cell subsets including effector (T eff), regulatory (T reg), and memory (T mem) cells are
characterized by distinct metabolic profiles that influence their differentiation and function …

The mechanisms by which regulatory T cells (Tregs) migrate to and function within the
hypoxic tumor microenvironment are unclear. Our studies indicate that specific ablation of …

Long-chain fatty acid (LCFA) oxidation has been shown to play an important role in
interleukin-4 (IL-4)-mediated macrophage polarization (M (IL-4)). However, many of these …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Mammalian developmental timing is adjustable in vivo by preserving pre-implantation
embryos in a dormant state called diapause. Inhibition of the growth regulator mTOR …