A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and …

Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and
neurodegenerative diseases are essential for increasing our understanding of underlying …

Many modern genomic data analyses require implementing regressions where the number
of parameters (p, eg, the number of marker effects) exceeds sample size (n). Implementing …

Both linear mixed models (LMMs) and sparse regression models are widely used in
genetics applications, including, recently, polygenic modeling in genome-wide association …

Genome-wide association studies (GWAS) are a standard approach for studying the
genetics of natural variation. A major concern in GWAS is the need to account for the …

The availability of genomewide dense markers brings opportunities and challenges to
breeding programs. An important question concerns the ways in which dense markers and …

Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

The scientific community is increasingly concerned with the proportion of published
“discoveries” that are not replicated in subsequent studies. The field of rodent behavioral …

Selection plans in plant and animal breeding are driven by genetic evaluation. Recent
developments suggest using massive genetic marker information, known as “genomic …

It is widely believed that environmental standardization is the best way to guarantee
reproducible results in animal experiments. However, mounting evidence indicates that …