Teratogen update: methotrexate
SC Hyoun, SG Običan, AR Scialli - Birth Defects Research Part …, 2012 - Wiley Online Library
Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase,
resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis …
resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis …
Congenital malformations attributed to prenatal exposure to cyclophosphamide
P Rengasamy - Anti-Cancer Agents in Medicinal Chemistry …, 2017 - ingentaconnect.com
Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is
also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and …
also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and …
Cyclophosphamide for lupus during pregnancy
MEB Clowse, L Magder, M Petri - Lupus, 2005 - journals.sagepub.com
Severe systemic lupus erythematosus often requires the use of cyclophosphamide in
women of reproductive age. As cyclophosphamide is generally avoided during pregnancy …
women of reproductive age. As cyclophosphamide is generally avoided during pregnancy …
Combined chemotherapy and teratogenicity
GA Paskulin, PR Gazzola Zen… - … Research Part A …, 2005 - Wiley Online Library
BACKGROUND The concomitant occurrence of breast cancer and pregnancy is relatively
uncommon. We report the case of a patient with syndactyly, cleft hands, and absence of …
uncommon. We report the case of a patient with syndactyly, cleft hands, and absence of …
Cancer chemotherapeutic agents as human teratogens
BACKGROUND Cancer is the second leading cause of death among women of reproductive
age. Although the coincidence of pregnancy and cancer is rare and treatment may …
age. Although the coincidence of pregnancy and cancer is rare and treatment may …
Breast cancer and pregnancy: challenges of chemotherapy
MS Lenhard, I Bauerfeind, M Untch - Critical Reviews in Oncology …, 2008 - Elsevier
BACKGROUND: Breast cancer is the second most frequently occurring malignancy during
pregnancy. As evidence-based data on diagnostics and treatment is lacking, current …
pregnancy. As evidence-based data on diagnostics and treatment is lacking, current …
Challenges to diagnosing colorectal cancer during pregnancy
M Yaghoobi, G Koren, I Nulman - Canadian Family Physician, 2009 - cfp.ca
ABSTRACT QUESTION My patient is 13 weeks pregnant and has experienced rectal
bleeding and vomiting. Should I send her for a colonoscopy to rule out colorectal …
bleeding and vomiting. Should I send her for a colonoscopy to rule out colorectal …
Specific congenital malformations after exposure to cyclophosphamide, epirubicin and 5-fluorouracil during the first trimester of pregnancy
M Leyder, M Laubach, M Breugelmans… - Gynecologic and …, 2011 - karger.com
The treatment of pregnant women with chemotherapeutic drugs leads to congenital
malformations in 10–20% of newborn children. We present a case of an ongoing 19-week …
malformations in 10–20% of newborn children. We present a case of an ongoing 19-week …
Management of breast cancer diagnosed during pregnancy
HS Rugo - Current treatment options in oncology, 2003 - Springer
Opinion statement Breast cancer during pregnancy is generally defined as cancer occurring
during pregnancy or within 1 year of delivery, although treatment options are the most …
during pregnancy or within 1 year of delivery, although treatment options are the most …
Disease-modifying antirheumatic drugs in pregnancy: current status and implications for the future
F Vroom, HEK de Walle, MAJF van de Laar… - Drug safety, 2006 - Springer
Drug use during pregnancy is sometimes unavoidable, especially in chronic inflammatory
diseases such as rheumatoid arthritis (RA). The use of disease-modifying antirheumatic …
diseases such as rheumatoid arthritis (RA). The use of disease-modifying antirheumatic …