The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be
phenotypically distinct from monocyte-derived macrophages. Whether TRMs and monocyte …

Background & Aims Little is known about the signaling pathways that initiate and promote
acute pancreatitis (AP). The pathogenesis of AP has been associated with abnormal …

Human in vitro gametogenesis may transform reproductive medicine. Human pluripotent
stem cells (hPSCs) have been induced into primordial germ cell–like cells (hPGCLCs); …

Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease
with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages …

Background Impaired or hyperactive pancreas regeneration after injury would cause
exocrine insufficiency or recurrent/chronic pancreatitis and potentially carcinogenesis …

We discuss how obesity may contribute to increasing acute pancreatitis incidence, the role
of lipolytic unsaturated fatty acid release in worsening acute pancreatitis, and potential …

Background & Aims Sustained activation of the cytosolic calcium concentration induces
injury to pancreatic acinar cells and necrosis. The calcium release–activated calcium …

The gut microbiome participates in numerous physiologic functions and communicates
intimately with the host immune system. Antimicrobial peptides are critical components of …