[HTML][HTML] Revisiting the matricellular concept
JE Murphy-Ullrich, EH Sage - Matrix Biology, 2014 - Elsevier
The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …
to account for the non-lethal phenotypes of mice with inactivated genes encoding …
Emerging functions of thrombospondin-1 in immunity
S Kaur, DD Roberts - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …
interacting with components of the extracellular matrix and with several cell surface …
Effect of stimulation time on the expression of human macrophage polarization markers
D Unuvar Purcu, A Korkmaz, S Gunalp, DG Helvaci… - PloS one, 2022 - journals.plos.org
Macrophages are highly plastic cells that can polarize into functionally distinct subsets in
vivo and in vitro in response to environmental signals. The development of protocols to …
vivo and in vitro in response to environmental signals. The development of protocols to …
Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity
The extracellular matrix (ECM) plays an important role in the maintenance of white adipose
tissue (WAT) architecture and function, and proper ECM remodeling is critical to support …
tissue (WAT) architecture and function, and proper ECM remodeling is critical to support …
[HTML][HTML] Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease
Background & Aims Thrombospondin 1 (TSP1) is a multifunctional matricellular protein. We
previously showed that TSP1 has an important role in obesity-associated metabolic …
previously showed that TSP1 has an important role in obesity-associated metabolic …
Thrombospondin1 antagonist peptide treatment attenuates obesity-associated chronic inflammation and metabolic disorders in a diet-induced obese mouse model
Q Zhou, T Gwag, S Wang - Scientific Reports, 2023 - nature.com
Abstract Thrombospondin1 (TSP1) is a multifunctional matricellular protein. Previously, we
demonstrated that TSP1 plays a pivotal role in obesity-related inflammation and insulin …
demonstrated that TSP1 plays a pivotal role in obesity-related inflammation and insulin …
Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity
Lipid accumulation in liver and skeletal muscle contributes to co-morbidities associated with
diabetes and obesity. We made a transgenic mouse in which the adiponectin (Adipoq) …
diabetes and obesity. We made a transgenic mouse in which the adiponectin (Adipoq) …
IKKβ is essential for adipocyte survival and adaptive adipose remodeling in obesity
SH Park, Z Liu, Y Sui, RN Helsley, B Zhu, DK Powell… - Diabetes, 2016 - Am Diabetes Assoc
IκB kinase β (IKKβ), a central coordinator of inflammatory responses through activation of
nuclear factor-κB (NF-κB), has been implicated as a critical molecular link between …
nuclear factor-κB (NF-κB), has been implicated as a critical molecular link between …
Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr−/− mice by targeting the TGFβ-Smad3 pathway
DHA (22: 6, ω3), but not EPA (20: 5, ω3), attenuates Western diet (WD)-induced hepatic
fibrosis in a Ldlr−/− mouse model of nonalcoholic steatohepatitis. We examined the …
fibrosis in a Ldlr−/− mouse model of nonalcoholic steatohepatitis. We examined the …
Improved β-cell function leads to improved glucose tolerance in a transgenic mouse expressing lipoprotein lipase in adipocytes
H Memetimin, B Zhu, S Lee, WS Katz, PA Kern… - Scientific Reports, 2022 - nature.com
Lipoprotein lipase (LPL) hydrolyzes the triglyceride core of lipoproteins and also functions
as a bridge, allowing for lipoprotein and cholesterol uptake. Transgenic mice expressing …
as a bridge, allowing for lipoprotein and cholesterol uptake. Transgenic mice expressing …