Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

Through neuromodulatory influences over fronto-striato-cerebellar circuits, dopamine and
noradrenaline play important roles in high-level executive functions often reported to be …

Signalling through dopamine D2 receptors governs physiological functions related to
locomotion, hormone production and drug abuse,,,,,,. D2 receptors are also known targets of …

Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 …

The manifestations of Parkinson's disease are caused by reduced dopaminergic innervation
of the striatum. Loss-of-function mutations in the DJ-1 gene cause early-onset familial …

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

The role of the D3 receptor has remained largely elusive before the development of
selective research tools, such as selective radioligands, antibodies, various highly specific …