Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

BACKGROUND One hundred years ago, experiments on beating frog hearts identified
acetylcholine (ACh) as the seminal neurotransmitter. Sixty years later, fractionation of the eel …

Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …

Alcohol is the most consumed and abused psychoactive drug globally, but the molecular
mechanisms driving alcohol action and its associated behaviors in the brain remain …

Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are
expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of pentameric, ligand-
gated ion channels that are located on the surface of neurons and non-neuronal cells and …

In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a
chemical signal into one that is electrical via ligand-gated ion flux through the central …

Chronic neuropathic pain is an increasingly prevalent societal issue that responds poorly to
existing therapeutic strategies. The α9α10 nicotinic acetylcholine receptor (nAChR) has …