Human prion diseases are rare neurodegenerative disorders related to prion protein
misfolding that can occur as sporadic, familial or acquired forms. In comparison to other …

Zoonoses are infections that spread naturally between species (sometimes by a vector) from
animals to other animal species or to humans or from humans to animals. Most of the …

Bovine spongiform encephalopathy (BSE) in cattle, the most likely cause of variant
Creutzfeldt–Jakob disease in humans, is thought to be caused by a unique infectious agent …

A panel of ruminant brain tissues were subjected to a Western immunoblotting technique
using two monoclonal antibodies (mAbs). The resultant prion protein (PrP) glycoforms …

A new variant of Creutzfeldt Jacob Disease (vCJD) was identified in humans and linked to
the consumption of Bovine Spongiform Encephalopathy (BSE)-infected meat products …

The intensified surveillance of scrapie in small ruminants in the European Union (EU) has
resulted in a substantial increase of the number of diagnosed cases. Four rapid tests which …

Our discovery of dominant-negative inhibition of prion formation in cultured cells provided an
explanation for the resistance of some sheep to scrapie and humans to Creutzfeldt–Jakob …

Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting
numerous mammalian species, including humans. The existence of heritable phenotypes of …

The discovery of molecular subtypes of the pathological prion protein PrP Sc has provided
the basis for a novel classification of human transmissible spongiform encephalopathies …

Background Diagnosis based on prion detection in lymph nodes of sheep and goats can
improve active surveillance for scrapie and, if it were circulating, for bovine spongiform …