Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many
substantia nigra (SN) dopamine neurons have already died. Now that therapies to block this …

Imaging techniques permit the study of the molecular interactions that underlie health and
disease. Each imaging technique collects unique chemical information about the cellular …

Secondary ion mass spectrometry (SIMS) has become an increasingly utilized tool in
biologically relevant studies. Of these, high lateral resolution methodologies using the …

The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons
in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in …

Metal elements represent some of the most fundamental chemical building blocks of life and
are required to sustain the growth, development, and sustenance of all living organisms and …

Copper is essential for life, and beyond its well-established ability to serve as a tightly
bound, redox-active active site cofactor for enzyme function, emerging data suggest that …

Secondary ion mass spectrometry (SIMS) has been increasingly recognized as a powerful
technique for visualizing molecular architectures in the fields of neurobiology and cell …