Increased understanding of the role of mitochondria under physiological and pathological
conditions parallels increased exploration of synthetic and natural compounds able to mimic …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

Significance: Superoxide dismutase (SOD) enzymes are indispensable and ubiquitous
antioxidant defenses maintaining the steady-state levels of O2·−; no wonder, thus, that their …

Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …

Manganese catalases (MnCAT) and superoxide dismutases (MnSOD) deplete hydrogen
peroxide and superoxide in cells through a ping-pong mechanism involving cyclic oxidation …

Superoxide radicals are one of the most toxic reactive oxygen species and its damaging
effects lead to a variety of detrimental health conditions including cardiovascular diseases …

Oxidative stress, a redox imbalance between the endogenous reactive species and
antioxidant systems, is common to numerous pathological conditions such as cancer, central …

MnTBAP is often referred to as an SOD mimic in numerous models of oxidative stress. We
have recently reported that pure MnTBAP does not dismute superoxide, but commercial/ill …

The most efficacious Mn (III) porphyrinic (MnPs) scavengers of reactive species have
positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic …