The role of alternative splicing in adaptation and evolution
Regulation of gene expression plays a central role in adaptive divergence and evolution.
Although the role of gene regulation in microevolutionary processes is gaining wide …
Although the role of gene regulation in microevolutionary processes is gaining wide …
[HTML][HTML] Context-specific regulation and function of mRNA alternative polyadenylation
S Mitschka, C Mayr - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability
Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …
associated with human traits and diseases. However, the functional interpretation of these …
Transcriptome variation in human tissues revealed by long-read sequencing
DA Glinos, G Garborcauskas, P Hoffman, N Ehsan… - Nature, 2022 - nature.com
Regulation of transcript structure generates transcript diversity and plays an important role in
human disease,,,,,–. The advent of long-read sequencing technologies offers the opportunity …
human disease,,,,,–. The advent of long-read sequencing technologies offers the opportunity …
[HTML][HTML] Deciphering the impact of genetic variation on human polyadenylation using APARENT2
Background 3′-end processing by cleavage and polyadenylation is an important and finely
tuned regulatory process during mRNA maturation. Numerous genetic variants are known to …
tuned regulatory process during mRNA maturation. Numerous genetic variants are known to …
[HTML][HTML] Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Background Alternative cleavage and polyadenylation (APA), an RNA processing event,
occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with …
occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with …
[HTML][HTML] Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
[HTML][HTML] Sites of transcription initiation drive mRNA isoform selection
C Alfonso-Gonzalez, I Legnini, S Holec, L Arrigoni… - Cell, 2023 - Elsevier
The generation of distinct messenger RNA isoforms through alternative RNA processing
modulates the expression and function of genes, often in a cell-type-specific manner. Here …
modulates the expression and function of genes, often in a cell-type-specific manner. Here …
[HTML][HTML] The impact of cell type and context-dependent regulatory variants on human immune traits
Background The vast majority of trait-associated variants identified using genome-wide
association studies (GWAS) are noncoding, and therefore assumed to impact gene …
association studies (GWAS) are noncoding, and therefore assumed to impact gene …
[PDF][PDF] Skipper analysis of eCLIP datasets enables sensitive detection of constrained translation factor binding sites
Technology for crosslinking and immunoprecipitation (CLIP) followed by sequencing (CLIP-
seq) has identified the transcriptomic targets of hundreds of RNA-binding proteins in cells …
seq) has identified the transcriptomic targets of hundreds of RNA-binding proteins in cells …