The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose
their characteristics and acquire mesenchymal traits to promote cell movement. This …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

Background Epithelial cell adhesion molecule (EpCAM) is known to highly expression and
promotes cancer progression in many cancer types, including colorectal cancer. While …

Background In colorectal cancer (CRC), the consensus molecular subtype 4 (CMS4) is
associated with therapy resistance and poor prognosis. Clinical diagnosis of CMS4 is …

Tumor heterogeneity, a hallmark of cancer, impairs the efficacy of cancer therapy and drives
tumor progression. Exploring inter-and intra-tumoral heterogeneity not only provides insights …

Phenotypic plasticity, defined as the ability of individual cells with stable genotypes to exert
different phenotypes upon exposure to specific environmental cues, represent the …

Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically
interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an …

Epigenetic modifications are defined as heritable changes in gene activity that do not
involve changes in the underlying DNA sequence. The oncogenic process is driven by the …