Mechanisms and regulation of defensins in host defense
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …
How many kinases are druggable? A review of our current understanding
There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …
A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting
compounds, which have multiple targets on a single pathogen, offer an effective approach to …
compounds, which have multiple targets on a single pathogen, offer an effective approach to …
Combatting fungal infections: Advances in antifungal polymeric nanomaterials
Fungal pathogens cause over 6.5 million life-threatening systemic infections annually, with
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …
A synthetic peptide mimic kills Candida albicans and synergistically prevents infection
S Schaefer, R Vij, JL Sprague, S Austermeier… - Nature …, 2024 - nature.com
More than two million people worldwide are affected by life-threatening, invasive fungal
infections annually. Candida species are the most common cause of nosocomial, invasive …
infections annually. Candida species are the most common cause of nosocomial, invasive …
Brilacidin, a novel antifungal agent against Cryptococcus neoformans
C Diehl, CF Pinzan, PA de Castro, E Delbaje… - Mbio, 2024 - journals.asm.org
Cryptococcus neoformans causes cryptococcosis, one of the most prevalent fungal
diseases, generally characterized by meningitis. There is a limited and not very effective …
diseases, generally characterized by meningitis. There is a limited and not very effective …
Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans
A Brakel, T Grochow, S Fritsche, D Knappe… - Frontiers in …, 2024 - frontiersin.org
Background Cryptococcosis and cryptococcal meningitis, caused by Cryptococcus
neoformans infections, lead to approximately 180,000 deaths per year, primarily in …
neoformans infections, lead to approximately 180,000 deaths per year, primarily in …
Various biomimetics, including peptides as antifungals
E Efremenko, A Aslanli, N Stepanov, O Senko… - Biomimetics, 2023 - mdpi.com
Biomimetics, which are similar to natural compounds that play an important role in the
metabolism, manifestation of functional activity and reproduction of various fungi, have a …
metabolism, manifestation of functional activity and reproduction of various fungi, have a …
Antistaphylococcal discovery pipeline; where are we now?
D Nawrot, W Ambrożkiewicz-Mosler, M Doležal… - European Journal of …, 2024 - Elsevier
The serious spread of antibiotic-resistant Staphylococcal aureus strains is alarming. This is
reflected by the measures governments and health-related bodies are offering to ease …
reflected by the measures governments and health-related bodies are offering to ease …
Impacts of hydrophobic mismatch on antimicrobial peptide efficacy and bilayer permeabilization
S Meier, ZM Ridgway, AL Picciano, GA Caputo - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance continues to be a major threat to world health, with the continued
emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an …
emergence of resistant bacterial strains. Antimicrobial peptides have emerged as an …