Multimodal characterization of murine gastruloid development
Gastruloids are 3D structures generated from pluripotent stem cells recapitulating
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …
[HTML][HTML] In vitro models of human hypoblast and mouse primitive endoderm
M Perera, JM Brickman - Current Opinion in Genetics & Development, 2023 - Elsevier
Highlights•Similarities and differences in the embryonic origin and differentiation of PrE
(mouse) compared to hypoblast (human) development.•Signficant aspects of signaling …
(mouse) compared to hypoblast (human) development.•Signficant aspects of signaling …
[HTML][HTML] In situ characterization of the tumor microenvironment
Highlights•Comprehensive TME characterization is required to understand therapy
resistance and sensitivity to current generations of therapeutics•Spatial profiling has …
resistance and sensitivity to current generations of therapeutics•Spatial profiling has …
The primitive endoderm supports lineage plasticity to enable regulative development
M Linneberg-Agerholm, AC Sell, A Redó-Riveiro… - Cell, 2024 - cell.com
Mammalian blastocyst formation involves the specification of the trophectoderm followed by
the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic …
the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic …
A single-cell atlas of pig gastrulation as a resource for comparative embryology
L Simpson, A Strange, D Klisch, S Kraunsoe… - Nature …, 2024 - nature.com
Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent
embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy …
embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy …
Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
Cell proliferation is fundamental for almost all stages of development and differentiation that
require an increase in cell number. Although cell cycle phase has been associated with …
require an increase in cell number. Although cell cycle phase has been associated with …
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
TE Knudsen, WB Hamilton, M Proks, M Lykkegaard… - Cell Systems, 2023 - cell.com
Cooperative DNA binding of transcription factors (TFs) integrates the cellular context to
support cell specification during development. Naive mouse embryonic stem cells are …
support cell specification during development. Naive mouse embryonic stem cells are …
Extraembryonic gut endoderm cells undergo programmed cell death during development
Despite a distinct developmental origin, extraembryonic cells in mice contribute to gut
endoderm and converge to transcriptionally resemble their embryonic counterparts. Notably …
endoderm and converge to transcriptionally resemble their embryonic counterparts. Notably …
Transcriptional heterogeneity and cell cycle regulation as central determinants of primitive endoderm priming
During embryonic development cells acquire identity as they proliferate, implying that an
intrinsic facet of cell fate choice requires coupling lineage decisions to cell division. How is …
intrinsic facet of cell fate choice requires coupling lineage decisions to cell division. How is …
Neighbor-specific gene expression revealed from physically interacting cells during mouse embryonic development
Development of multicellular organisms is orchestrated by persistent cell–cell
communication between neighboring partners. Direct interaction between different cell types …
communication between neighboring partners. Direct interaction between different cell types …