A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions

TN Jarada, JG Rokne, R Alhajj - Journal of cheminformatics, 2020 - Springer
Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs
and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an …

Drug repurposing using real-world data

GSQ Tan, EK Sloan, P Lambert, CMJ Kirkpatrick… - Drug discovery today, 2023 - Elsevier
Highlights•250 records, including 144 original studies, met the eligibility criteria for inclusion
in this review.•Studies evaluated repurposing mainly for cardiovascular disease, COVID-19 …

Explainable artificial intelligence for predictive modeling in healthcare

CC Yang - Journal of healthcare informatics research, 2022 - Springer
The principle behind artificial intelligence is mimicking human intelligence in the way that it
can perform tasks, recognize patterns, or predict outcomes through learning from the …

PharmGKB, an integrated resource of pharmacogenomic knowledge

L Gong, M Whirl‐Carrillo, TE Klein - Current protocols, 2021 - Wiley Online Library
Abstract The Pharmacogenomics Knowledgebase (PharmGKB) is an integrated online
knowledge resource for the understanding of how genetic variation contributes to variation …

Deep-learning-based drug recommendation and adr detection healthcare model on social media

S Dongre, J Agrawal - IEEE Transactions on Computational …, 2023 - ieeexplore.ieee.org
The rapid rise of healthcare social media websites captures a significant amount of
healthcare information, leading to mining medical content for pharmacovigilance …

The heterogeneous pharmacological medical biochemical network PharMeBINet

C Königs, M Friedrichs, T Dietrich - Scientific Data, 2022 - nature.com
Heterogeneous biomedical pharmacological databases are important for multiple fields in
bioinformatics. Hetionet is a freely available database combining diverse entities and …

AI and GNN model for predictive analytics on patient data and its usefulness in digital healthcare technologies

A Sharma, PK Singh, P Nikashina, V Gavrilenko… - IoT, Big Data and AI for …, 2023 - Springer
The confidence of an AI predictive model increases with algorithm correction (training). In
radiology, pathology, and dermatology, AI is successfully used for image analysis …

A review of recent developments and progress in computational drug repositioning

W Shi, X Chen, L Deng - Current Pharmaceutical Design, 2020 - ingentaconnect.com
Computational drug repositioning is an efficient approach towards discovering new
indications for existing drugs. In recent years, with the accumulation of online health-related …

Human protein complex-based drug signatures for personalized cancer medicine

F Wang, Y Ding, X Lei, B Liao… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
Disease signature-based drug repositioning approaches typically first identify a disease
signature from gene expression profiles of disease samples to represent a particular …

Kinetics studies of epoxidation and oxirane cleavage-epoxidized palm kernel oil

MJ Jalil, AFM Yamin, MSM Zaini… - … Recent Patents on …, 2020 - ingentaconnect.com
Background: Studies pertaining to the epoxidation of fatty acids, garnered much interest in
recent years due to the rising demand of eco-friendly epoxides derived from vegetable oils …