Individual differences in delay discounting—how much we discount future compared to
immediate rewards—are associated with general life outcomes, psychopathology, and …

For decades, aberrant dopamine transmission has been proposed to play a central role in
schizophrenia pathophysiology. These theories are supported by human in vivo molecular …

Convolutional neural networks (CNNs) have achieved state-of-the-art performance for white
matter (WM) tract segmentation based on diffusion magnetic resonance imaging (dMRI). The …

Diffusion tractography allows identification and measurement of structural tracts in the
human brain previously associated with motivated behavior in animal models. Recent …

The ventral tegmental area (VTA), nucleus accumbens (NAcc), and prefrontal cortex (PFC)
are essential for experiencing pleasure and initiating motivated behaviour. The VTA, NAcc …

Motivation is a powerful driver of learning and memory. Functional MRI studies show that
interactions among the dopaminergic midbrain substantia nigra/ventral tegmental area …

Emotions are time-varying internal states that promote survival in the face of dynamic
environments and shifting homeostatic needs. Research in non-human organisms has …

Uncertainties concerning anatomy and function of cortico-subcortical projections have
arisen during the recent years. A clear distinction between cortico-subthalamic (hyperdirect) …

This study aimed to investigate structural and functional alterations of the reward system and
the neurobiology of craving in alcohol use disorder (AUD). We hypothesized reduced …

One of the most robust neurochemical abnormalities reported in patients with schizophrenia
is an increase in dopamine (DA) synthesis and release, restricted to the dorsal striatum (DS) …