Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

Epigenetic inheritance is fundamentally important to cellular differentiation and
developmental plasticity. In this review, we provide an introduction to the field of molecular …

During embryogenesis, the genome shifts from transcriptionally quiescent to extensively
active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer …

Linker histone H1 is an important structural component of chromatin that stabilizes the
nucleosome and compacts the nucleofilament into higher-order structures. The biology of …

DNA double-strand break (DSB) repair depends on the ataxia telangiectasia mutated (ATM)
kinase that phosphorylates the conserved C-terminal SQ motif present in the histone variant …

Aquatic species are increasingly confronted with environmental stressors because of climate
change. Although molecular technologies have advanced our understanding of how …

In response to heavy metal stress, the RNA-binding protein (RBP) gawky translocates into
the nucleus and acts as a chromatin-interacting factor to activate the transcription of many …

H2A variants are histones that carry out specialized nucleosome function during the
eukaryote genome packaging. Most genes encoding H2A histone variants arose in the …

Assembly of DNA into chromatin requires a delicate balancing act, as both dearth and
excess of histones severely disrupt chromatin function [1–3]. In particular, cells need to …

Histone acetylation is essential for initiating and maintaining a permissive chromatin
conformation and gene transcription. Dysregulation of histone acetylation can contribute to …