Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
[HTML][HTML] A red carpet for iron metabolism
200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …
The role of iron regulation in immunometabolism and immune-related disease
Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …
regulate their function under different micro-environmental and (patho-)-physiological …
Driving E3 ligase substrate specificity for targeted protein degradation: lessons from nature and the laboratory
Methods to direct the degradation of protein targets with proximity-inducing molecules that
coopt the cellular degradation machinery are advancing in leaps and bounds, and diverse …
coopt the cellular degradation machinery are advancing in leaps and bounds, and diverse …
The IRP/IRE system in vivo: insights from mouse models
N Wilkinson, K Pantopoulos - Frontiers in pharmacology, 2014 - frontiersin.org
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) post-transcriptionally control the
expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism …
expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism …
[HTML][HTML] Mammalian iron metabolism and its control by iron regulatory proteins
CP Anderson, M Shen, RS Eisenstein… - Biochimica et Biophysica …, 2012 - Elsevier
Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …
Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors
Iron uptake and metabolism are tightly regulated in both plants and animals. In Arabidopsis
(Arabidopsis thaliana), BRUTUS (BTS), which contains three hemerythrin (HHE) domains …
(Arabidopsis thaliana), BRUTUS (BTS), which contains three hemerythrin (HHE) domains …
The active role of vitamin C in mammalian iron metabolism: much more than just enhanced iron absorption!
DJR Lane, DR Richardson - Free radical biology and medicine, 2014 - Elsevier
Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone …
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone …
Inflaming the brain with iron
Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
[HTML][HTML] FBXL5 regulates IRP2 stability in iron homeostasis via an oxygen-responsive [2Fe2S] cluster
H Wang, H Shi, M Rajan, ER Canarie, S Hong… - Molecular cell, 2020 - cell.com
Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory
protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical …
protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical …