Hypertension management in patients with cardiovascular comorbidities

L Lauder, F Mahfoud, M Azizi, DL Bhatt… - European Heart …, 2023 - academic.oup.com
Arterial hypertension is a leading cause of death globally. Due to ageing, the rising
incidence of obesity, and socioeconomic and environmental changes, its incidence …

The sympathetic nervous system alterations in human hypertension

G Grassi, A Mark, M Esler - Circulation research, 2015 - Am Heart Assoc
Several articles have dealt with the importance and mechanisms of the sympathetic nervous
system alterations in experimental animal models of hypertension. This review addresses …

Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study

H Krum, MP Schlaich, PA Sobotka, M Böhm, F Mahfoud… - The Lancet, 2014 - thelancet.com
Background Renal denervation (RDN) with radiofrequency ablation substantially reduces
blood pressure in patients with treatment-resistant hypertension. We assessed the long-term …

[PDF][PDF] 难治性高血压诊断治疗中国专家共识

孙宁玲, 霍勇, 王继光, 李南方, 陶军, 李勇, 严晓伟… - 2013 - i.heartabc.com
难治性高血压&7>:):;(-; KAB> 7;>-:) 1-! PT'是高血压治疗中的一个难点# 随着人口老龄化以及
肥胖+ 睡眠呼吸暂停低通气综合征+ 慢性肾脏病等疾病的增多! PT 成为越来越常见的临床问题# …

Hypertension in chronic kidney disease

SM Hamrahian, B Falkner - Hypertension: from basic research to clinical …, 2017 - Springer
Hypertension, a global public health problem, is currently the leading factor in the global
burden of disease. It is the major modifiable risk factor for heart disease, stroke and kidney …

New approaches in the treatment of hypertension

S Oparil, RE Schmieder - Circulation research, 2015 - Am Heart Assoc
Hypertension is the most common modifiable risk factor for cardiovascular disease and
death, and lowering blood pressure with antihypertensive drugs reduces target organ …

Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial

MD Esler, H Krum, M Schlaich, RE Schmieder… - Circulation, 2012 - Am Heart Assoc
Background—Renal sympathetic nerve activation contributes to the pathogenesis of
hypertension. Symplicity HTN-2, a multicenter, randomized trial, demonstrated that catheter …

Expert consensus document from the European Society of Cardiology on catheter-based renal denervation

F Mahfoud, TF Lüscher, B Andersson… - European Heart …, 2013 - academic.oup.com
Hypertension is highly prevalent and one of the most frequent chronic diseases worldwide. 1
It has been suggested that over the next two decades up to 50% of the adult population will …

Circadian clocks of the kidney: function, mechanism, and regulation

HM Costello, JG Johnston, A Juffre… - Physiological …, 2022 - journals.physiology.org
An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral
circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal …

Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension

D Hering, EA Lambert, P Marusic, AS Walton… - …, 2013 - Am Heart Assoc
Renal denervation (RDN) has been shown to reduce blood pressure (BP) and muscle
sympathetic nerve activity (MSNA) in patients with resistant hypertension. The mechanisms …