New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

[HTML][HTML] Retinopathy of prematurity: A review of pathophysiology and signaling pathways

M Fevereiro-Martins, C Marques-Neves… - survey of …, 2023 - Elsevier
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

[HTML][HTML] Organ-organ communication: The liver's perspective

F Wang, KF So, J Xiao, H Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Communication between organs participates in most physiological and pathological events.
Owing to the importance of precise coordination among the liver and virtually all organs in …

Dyslipidemia in retinal metabolic disorders

Z Fu, CT Chen, G Cagnone, E Heckel… - EMBO Molecular …, 2019 - embopress.org
The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and
have the highest density of mitochondria of any cell in the body. Both physiological and …

Retinopathy of prematurity: Metabolic risk factors

Z Fu, AK Nilsson, A Hellstrom, LEH Smith - Elife, 2022 - elifesciences.org
At preterm birth, the retina is incompletely vascularized. Retinopathy of prematurity (ROP) is
initiated by the postnatal suppression of physiological retinal vascular development that …

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

A Salminen, K Kaarniranta, A Kauppinen - Cellular signalling, 2017 - Elsevier
FGF21 is a multifunctional metabolic and stress hormone which is normally expressed in
liver but cellular stress, eg mitochondrial or endoplasmic reticulum (ER) stress, can induce …

[HTML][HTML] Determining the role of SGLT2 inhibition with dapagliflozin in the development of diabetic retinopathy

LY Herat, JR Matthews, WE Ong… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: Diabetic retinopathy (DR) is a major cause of blindness globally. Sodium
Glucose Cotransporter-2 (SGLT2) inhibitors have been demonstrated to exert cardiorenal …

Insights into the liver-eyes connections, from epidemiological, mechanical studies to clinical translation

J Wu, C Duan, Y Yang, Z Wang, C Tan, C Han… - Journal of Translational …, 2023 - Springer
Maintenance of internal homeostasis is a sophisticated process, during which almost all
organs get involved. Liver plays a central role in metabolism and involves in endocrine …

Pemafibrate protects against retinal dysfunction in a murine model of diabetic retinopathy

Y Tomita, D Lee, Y Miwa, X Jiang, M Ohta… - International journal of …, 2020 - mdpi.com
Diabetic retinopathy (DR) is one of the leading causes of blindness globally. Retinal
neuronal abnormalities occur in the early stage in DR. Therefore, maintaining retinal …

Beyond the liver: Liver-eye communication in clinical and experimental aspects

TH Yuan, ZS Yue, GH Zhang, L Wang… - Frontiers in Molecular …, 2021 - frontiersin.org
The communication between organs participates in the regulation of body homeostasis
under physiological conditions and the progression and adaptation of diseases under …