The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor
23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes …

Oxidative stress and the accompanying chronic inflammation constitute an important
metabolic problem that may lead to pathology, especially when the body is exposed to …

The NLRP3 inflammasome is a critical component of the innate immune response. NLRP3
activation is a tightly controlled process involving an initial priming to express NLRP3, pro-IL …

The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation
against microbial threats, crystals, and danger-associated molecular patterns (DAMPs) …

Epilepsy is a brain disorder characterized by recurrent seizures, which are brief episodes of
abnormal electrical activity in the brain and involuntary movement that can lead to physical …

As a critical sensor protein, NLRP3 detects cellular perturbation caused by diverse
exogenous and endogenous stimuli. NLRP3 activation requires domain rotation within the …

The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern
recognition receptor in the innate immune system. Its overactivation leads to the production …

Aberrant activation of NLRP3 inflammasome is involved in various inflammatory diseases,
making it a promising target for therapeutic intervention. NEK7, a member of the NIMA …

Phase separation is a thermodynamic process used by all living organisms since the origin
of life to rapidly assemble and disassemble membraneless condensates in response to …

摘要心血管疾病(cardiovascular diseases, CVD) 是我国居民死亡的首要原因,
严重影响患者的生存质量. CVD 病理机制较为复杂, 以慢性低度炎症为主要特征 …