Recent applications of barbituric acid in multicomponent reactions

GM Ziarani, F Aleali, N Lashgari - RSC advances, 2016 - pubs.rsc.org
Barbituric acid has been utilized in the design and synthesis of diverse types of heterocyclic
and carbocyclic compounds and considered as an important building block in organic …

Recent green chemistry approaches for pyrimidine derivatives as a potential anti-cancer agent: An overview (2013–2023)

K Kajal, R Shakya, M Rashid, V Nigam… - Sustainable Chemistry …, 2024 - Elsevier
The widespread scrutiny of orthodox synthetic techniques for the fabrication of nitrogen-
embracing heteroatom segments has shifted scholar's focus to innovative environmentally …

[HTML][HTML] Synthesis, characterization, biological activities and molecular modeling of Schiff bases of benzene sulfonamides bearing curcumin scaffold

M Ahmed, MA Qadir, MI Shafiq, M Muddassar… - Arabian journal of …, 2019 - Elsevier
Curcumin has shown large number of pharmacological properties against different
phenotypes of various disease models. Different synthetic routes have been employed to …

Treatment with a new barbituric acid derivative suppresses diet-induced metabolic dysfunction and non-alcoholic fatty liver disease in mice

FM Suk, FY Hsu, MH Hsu, WC Chiu, CC Fang, TL Chen… - Life Sciences, 2024 - Elsevier
Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease, often accompanied by obesity, diabetes, and increased risks of depression and …

Treatment with a new barbituric acid derivative exerts antiproliferative and antimigratory effects against sorafenib resistance in hepatocellular carcinoma

YJ Liao, SM Hsu, CY Chien, YH Wang, MH Hsu… - Molecules, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Sorafenib,
a multikinase inhibitor, is the first-line drug approved by the Food and Drug Administration …

Antifibrotic effects of a barbituric acid derivative on liver fibrosis by blocking the NF-κB signaling pathway in hepatic stellate cells

YH Wang, FM Suk, CL Liu, TL Chen, YC Twu… - Frontiers in …, 2020 - frontiersin.org
Hepatic stellate cells (HSCs) are the major profibrogenic cells that promote the
pathogenesis of liver fibrosis. The crosstalk between transforming growth factor-β1 (TGF-β1) …

Preparation and application of triphenyl (propyl-3-hydrogen sulfate) phosphonium bromide as new efficient ionic liquid catalyst for synthesis of 5-arylidene barbituric …

S Karami, AR Momeni, J Albadi - Research on Chemical Intermediates, 2019 - Springer
We report synthesis of triphenyl (propyl-3-hydrogen sulfate) phosphonium bromide
([TPPHSP] Br) as a reusable green Brønsted-acidic ionic liquid catalyst and its application …

One‐pot, Three‐component Synthesis of a Series of New Bis‐pyrrolo[2,3‐d]pyrimidines in the Presence of TPAB under Reflux Conditions

M Ahmadi Sabegh, J Khalafy… - Journal of Heterocyclic …, 2018 - Wiley Online Library
A one‐pot, three‐component reaction of 1, 4‐phenylene‐bis‐glyoxal, 6‐aminouracils, and
dimedone or barbituric acid derivatives in the presence of tetrapropylammonium bromide (5 …

Synthesis of cobalt-ferrite and zinc oxide metal nanoparticles based-bentonite using SDS and their investigation as catalysts in synthesis of benzylbarbiturocoumarins

P Baminejhad, E Sheikhhosseini… - Frontiers in …, 2024 - frontiersin.org
In this research, a suitable and efficient CoFe2O4@ ZnO@ Bentonite nano-catalyst was
designed and synthesized by using zinc oxide (ZnO) and cobalt ferrite (CoFe2O4) …

Silica sodium carbonate catalyzed in water synthesis of novel benzylbarbiturocoumarin derivatives

K Eskandari, B Karami, M Farahi, V Mouzari - Tetrahedron Letters, 2016 - Elsevier
Novel benzylbarbiturocoumarins were synthesized under mild conditions in the presence of
silica sodium carbonate as a supported solid base catalyst. Catalytic condensation between …