Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …

The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …

Robust biomarkers of chronological age have been developed in humans and model
mammalian species such as rats and mice using DNA methylation data. The concept of …

The oocyte is considered to be the largest cell in mammalian species. Women hoping to
become pregnant face a ticking biological clock. This is becoming increasingly challenging …

The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory
care and experimental manipulation, and unique biology, is the most used laboratory …

The post-reproductive phase or menopause in females is triggered by a physiological timer
that depends on a threshold of follicle number in the ovary. Curiously, reproductive …