Adenosine kinase: exploitation for therapeutic gain

D Boison, SPH Alexander - Pharmacological reviews, 2013 - Elsevier
Abstract Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine …

[HTML][HTML] Insights into Peptidyl-Prolyl cis-trans Isomerases from Clinically Important Protozoans: From Structure to Potential Biotechnological Applications

V Aranda-Chan, RE Cárdenas-Guerra… - Pathogens, 2024 - mdpi.com
Peptidyl-prolyl cis/trans isomerases (PPIases) are present in a wide variety of
microorganisms, including protozoan parasites such as Trypanosoma cruzi, Trypanosoma …

Transcriptomics throughout the life cycle of Leishmania infantum: high down-regulation rate in the amastigote stage

PJ Alcolea, A Alonso, MJ Gómez, I Moreno… - International journal for …, 2010 - Elsevier
Leishmania infantum is the causative agent of zoonotic visceral leishmaniasis in the
Mediterranean Basin. The promastigote and amastigote stages alternate in the life cycle of …

[HTML][HTML] Genome-wide analysis reveals increased levels of transcripts related with infectivity in peanut lectin non-agglutinated promastigotes of Leishmania infantum

PJ Alcolea, A Alonso, A Sánchez-Gorostiaga… - Genomics, 2009 - Elsevier
Metacyclic promastigotes are transmitted during bloodmeals after development inside the
gut of the sandfly vector. The isolation from axenic cultures of procyclic and metacyclic …

Interplay between a cytosolic and a cell surface carbonic anhydrase in pH homeostasis and acid tolerance of Leishmania

DS Pal, M Abbasi, DK Mondal… - Journal of cell …, 2017 - journals.biologists.com
Leishmania parasites have evolved to endure the acidic phagolysosomal environment
within host macrophages. How Leishmania cells maintain near-neutral intracellular pH and …

Molecular aspects of cyclophilins mediating therapeutic actions of their ligands

A Galat, J Bua - Cellular and molecular life sciences, 2010 - Springer
Cyclosporine A (CsA) is an immunosuppressive cyclic peptide that binds with a high affinity
to 18 kDa human cyclophilin-A (hCyPA). CsA and its several natural derivatives have some …

Can the jigsaw puzzle model of protein folding re‐assemble a hydrophobic core?

G Biswas, S Ghosh, S Basu… - Proteins: Structure …, 2022 - Wiley Online Library
According to the “jigsaw puzzle” model of protein folding, the isomorphism between
sequence and structure is substantially determined by the specific geometry of side‐chain …

Increased abundance of proteins involved in resistance to oxidative and nitrosative stress at the last stages of growth and development of Leishmania amazonensis …

PJ Alcolea, A Alonso, F García-Tabares, MC Mena… - PLoS …, 2016 - journals.plos.org
Leishmania amazonensis is one of the major etiological agents of the neglected,
stigmatizing disease termed american cutaneous leishmaniasis (ACL). ACL is a zoonosis …

The contribution of DNA microarray technology to gene expression profiling in Leishmania spp.: A retrospective view

A Alonso, V Larraga, PJ Alcolea - Acta Tropica, 2018 - Elsevier
The first completed genome project of any living organism, excluding viruses, was of the
gammaproteobacteria Haemophilus influenzae in 1995. Until the last decade, genome …

Cyclophilin-mediated reactivation pathway of inactive adenosine kinase aggregates

D Mukherjee, H Patra, A Laskar, A Dasgupta… - Archives of biochemistry …, 2013 - Elsevier
Monomeric adenosine kinase (AdK), a pivotal salvage enzyme of the purine auxotrophic
parasite, Leishmania donovani, tends to aggregate naturally or selectively in presence of …