Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Membrane potential (Vm), the voltage across the plasma membrane, arises because of the
presence of different ion channels/transporters with specific ion selectivity and permeability …

PURPOSE Preventing metastases by using perioperative interventions has not been
adequately explored. Local anesthesia blocks voltage-gated sodium channels and thereby …

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral
to metastasis (eg, proliferation, motility, secretion, and invasion), although their contribution …

Changes of the electrical charges across the surface cell membrane are absolutely
necessary to maintain cellular homeostasis in physiological as well as in pathological …

The Hodgkin-Huxley formulation, at its 60th anniversary, remains a bastion of neuroscience.
Sodium channels Nav1. 1–Nav1. 3 and Nav1. 6–Nav1. 9 support electrogenesis in neurons …

Cancer is a disease with marked heterogeneity in both response to therapy and survival.
Clinical and histopathological characteristics have long determined prognosis and therapy …

Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a
pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in …

Abstract Voltage-gated Na+ channels (VGSCs) are heteromeric membrane protein
complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits …

The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …