Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Sclerostin, the product of the SOST gene, is a secreted inhibitor of Wnt signaling that is
produced by osteocytes to regulate bone formation. While it is often considered an osteocyte …

The murine epidermis with its hair follicles represents an invaluable model system for tissue
regeneration and stem cell research. Here we used single-cell RNA-sequencing to reveal …

Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that
antagonizes the profound osteoanabolic capacity of activated Wnt/β-catenin signaling, but …

Skeletal integrity is maintained by a meticulous balance between bone resorption and bone
formation, and recent studies have revealed the essential role of canonical Wnt signaling …

With very few exceptions, all adult tissues in mammals are maintained and can be renewed
by stem cells that self-renew and generate the committed progeny required. These functions …

Osteoporosis is characterized by reduced bone mass and disruption of bone architecture,
resulting in increased risk of fragility fractures and significant long-term disability. Although …

Exposure to the space environment induces a number of pathophysiological outcomes in
astronauts, including bone demineralization, sleep disorders, circadian clock dysregulation …

Sclerostin has been identified as an important regulator of bone homeostasis through
inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of …

Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing
osteocytes. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly …