Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

As the up-and-comer in the development of RNA nanotechnology, RNA nanomaterials
based on functionalized rolling circle transcription (RCT) have become promising carriers for …

RNA nanotechnology, including rolling circle transcription (RCT), has gained increasing
interest as a fascinating siRNA delivery nanoplatform for biostable and tumor-targetable …

Nucleic acid nanotechnology is a powerful tool in the fields of biosensing and nanomedicine
owing to their high editability and easy synthesis and modification. Artificial nucleic acid …

Gene knockdown by siRNA offers an unrestricted choice of targets and specificity based on
the principle of complementary Watson–Crick base pairing with mRNA. However, the …

Combining the killing ability of chemotherapy drugs on tumor cells with the inhibiting ability
of genetic drugs on tumor cell growth, a dual drug delivery system loaded with therapy drugs …

Hematological cancers encompass a diverse group of malignancies affecting the blood,
bone marrow, lymph nodes, and spleen. These disorders present unique challenges due to …

A fundamental understanding of the design of polymer ligands of proximal enzymes is
essential for the precise targeting of cancer cells, but it is still in its infancy. In this study, we …

In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising
biomaterial for the development of drug delivery systems. Due to its unique properties, such …

Hematologic malignancies (HMs), also referred to as hematological or blood cancers, pose
significant threats to patients as they impact the blood, bone marrow, and lymphatic system …