Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

Atypical antipsychotic drugs were introduced in the early 1990s. Unlike typical
antipsychotics, which are effective only against positive symptoms of schizophrenia, atypical …

The neurotransmitter histamine receives less attention compared with other biogenic
amines, because of its moderate action in the central nervous system (CNS). However …

The striatum contains a high density of histamine H3 receptors, but their role in striatal
function is poorly understood. Previous studies have demonstrated antagonistic interactions …

Within the recent years novel lead optimisations for histamine H3 receptor antagonists made
their way from bench to bedside. Structure–activity relationships, cross-affinities and side …

Background and purpose: Functional interactions between the G protein‐coupled dopamine
D1 and histamine H3 receptors have been described in the brain. In the present study we …

Previously, using artificial cell systems, we identified receptor heteromers between the
dopamine D 1 or D 2 receptors and the histamine H 3 receptor. In addition, we demonstrated …

The neuromodulator histamine is released throughout the brain during periods of
wakefulness. Combined with an abundant expression of histamine receptors, this suggests …

The substantia nigra pars reticulata (SNr) plays a key role in basal ganglia function.
Projections from multiple basal ganglia nuclei converge at the SNr to regulate nigrothalamic …