Specific mechanical energy (SME) is a frequently overlooked but essential parameter of hot-
melt extrusion (HME). It can determine whether an amorphous solid dispersion (ASD) can …

Solid-state NMR has been increasingly recognized as a high-resolution and versatile
spectroscopic tool to characterize drug substances and products. However, the analysis of …

Indomethacin is a clinically classical non‐steroidal anti‐inflammatory drug that has been
marketed since 1965. The third polymorph, Form δ, was discovered by both melt and …

Identification of a thermodynamically stable polymorph is an important step in the early stage
of drug development. Ritonavir (RIT) is a well-known case where the most stable polymorph …

Griseofulvin (GSF) is a clinically used antifungal drug that was reported to have three true
polymorphs (Forms I–III) over the past eight decades. Here, we present the discovery of two …

Protons represent the most NMR-sensitive nucleus in pharmaceutical compounds.
Therefore, proton-detected solid-state NMR techniques under fast magic angle spinning are …

Islatravir, a highly potent nucleoside reverse transcriptase translocation inhibitor (NRTTI) for
the treatment of HIV, has great potential to be formulated as ethylene-vinyl acetate (EVA) …

Islatravir (MK-8591), a highly potent nucleoside reverse transcriptase translocation inhibitor,
is being developed to stem the spread of global HIV infections. Following a nine-enzyme in …

A rare example of crystal form-dependent, gamma radiation-induced degradation is
presented. Islatravir is known to exist in several polymorphic forms, but only one of these …

Salt formation is a useful technique for improving the solubility of active pharmaceutical
ingredients (APIs). For instance, a nonsteroidal anti-inflammatory drug, diclofenac (DIC), is …