[HTML][HTML] RET signaling in breast cancer therapeutic resistance and metastasis
RET, a single-pass receptor tyrosine kinase encoded on human chromosome 10, is well
known to the field of developmental biology for its role in the ontogenesis of the central and …
known to the field of developmental biology for its role in the ontogenesis of the central and …
[HTML][HTML] Precision medicine based on tumorigenic signaling pathways for triple‑negative breast cancer
N Wu, J Zhang, J Zhao, K Mu, J Zhang… - Oncology …, 2018 - spandidos-publications.com
As a clinically heterogeneous subtype of breast cancer, triple‑negative breast cancer
(TNBC) is associated with a poor clinical outcome and a high relapse rate. Conventional …
(TNBC) is associated with a poor clinical outcome and a high relapse rate. Conventional …
[HTML][HTML] ZDHHC2-mediated AGK palmitoylation activates AKT–mTOR signaling to reduce sunitinib sensitivity in renal cell carcinoma
Y Sun, L Zhu, P Liu, H Zhang, F Guo, X Jin - Cancer research, 2023 - AACR
Tyrosine kinase inhibitors (TKI) that can suppress the VEGF signaling pathway and
angiogenesis have been developed to impede the progression of malignant tumors and …
angiogenesis have been developed to impede the progression of malignant tumors and …
Reciprocal regulation of Hsa-miR-1 and long noncoding RNA MALAT1 promotes triple-negative breast cancer development
C Jin, B Yan, Q Lu, Y Lin, L Ma - Tumor Biology, 2016 - Springer
Recent studies demonstrated that long noncoding RNAs (lncRNAs) have a critical role in the
regulation of cancer progression and metastasis. However, little is known about the …
regulation of cancer progression and metastasis. However, little is known about the …
[HTML][HTML] NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology
A Mock, MV Teleanu, S Kreutzfeldt, CE Heilig… - NPJ Precision …, 2023 - nature.com
Abstract Analysis of selected cancer genes has become an important tool in precision
oncology but cannot fully capture the molecular features and, most importantly …
oncology but cannot fully capture the molecular features and, most importantly …
[HTML][HTML] Transcriptome profiling for precision cancer medicine using shallow nanopore cDNA sequencing
Transcriptome profiling is a mainstay of translational cancer research and is increasingly
finding its way into precision oncology. While bulk RNA sequencing (RNA-seq) is widely …
finding its way into precision oncology. While bulk RNA sequencing (RNA-seq) is widely …
Newcastle disease virus induces clathrin-mediated endocytosis to establish infection through the activation of PI3K/AKT signaling pathway by VEGFR2
L Fan, H Xiao, J Ren, Y Hou, J Cai, W Wu… - Journal of …, 2024 - journals.asm.org
ABSTRACT The phosphatidyl-inositol 3-kinase/serine-threonine kinase (PI3K/AKT)
signaling pathway constitutes a classical phosphorylation cascade that integrates tyrosine …
signaling pathway constitutes a classical phosphorylation cascade that integrates tyrosine …
Novel insight into triple-negative breast cancers, the emerging role of angiogenesis, and antiangiogenic therapy
C Braicu, R Chiorean, A Irimie, S Chira… - Expert reviews in …, 2016 - cambridge.org
Triple-negative breast cancer (TNBC) is a heterogeneous group of tumours characterised by
lack of expression of oestrogen-, progesterone-and human epidermal growth factor …
lack of expression of oestrogen-, progesterone-and human epidermal growth factor …
NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model
Abstract Neuropilin-1 (NRP-1) is an extra-cellular receptor for the main Vascular Endothelial
Growth Factor over-expressed in tumour tissues, VEGF-A 165. Consequently, NRP-1 is …
Growth Factor over-expressed in tumour tissues, VEGF-A 165. Consequently, NRP-1 is …
EGFR is regulated by TFAP2C in luminal breast cancer and is a target for vandetanib
JP De Andrade, JM Park, VW Gu, GW Woodfield… - Molecular cancer …, 2016 - AACR
Expression of TFAP2C in luminal breast cancer is associated with reduced survival and
hormone resistance, partially explained through regulation of RET. TFAP2C also regulates …
hormone resistance, partially explained through regulation of RET. TFAP2C also regulates …