We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-
growing technique for visualization of the spatial distribution of the small molecular and …

Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

Primary aldosteronism (PA) is an endocrinopathy characterized by dysregulated
aldosterone production that occurs despite suppression of renin and angiotensin II, and that …

The clinical characteristics and outcomes in patients with clinical aldosterone-producing
adenomas harboring KCNJ5 mutations with or without subclinical hypercortisolism remain …

Identifying and mapping steroids in tissues can provide opportunities for biomarker
discovery, the interrogation of disease progression, and new therapeutics. Although …

Steroids are present in all animals and plants, from mammals to prokaryotes. In the medical
field, steroids are commonly classified as glucocorticoids, mineralocorticoids, and gonadal …

Visualizing tissue distribution of steroid hormones is a promising application of MALDI mass
spectrometry imaging (MSI). On-tissue chemical derivatization using Girard's T reagent has …

Context The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and
reticularis. Aldosterone-producing cell clusters (APCCs) that strongly express aldosterone …

Aldosterone-producing adenomas (APAs) are one of the main causes of primary
aldosteronism and the most prevalent surgically correctable form of hypertension …