Therapeutic T cell engineering
M Sadelain, I Rivière, S Riddell - Nature, 2017 - nature.com
Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …
Programming CAR-T cells to kill cancer
T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour
antigens have led to high complete response rates in patients with haematologic …
antigens have led to high complete response rates in patients with haematologic …
Advancing cell-based cancer immunotherapy through stem cell engineering
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …
treatment of hematological malignancies. Although an important step forward for the field …
Cancer regression in patients after transfer of genetically engineered lymphocytes
Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to
mediate objective cancer regression in human patients with metastatic melanoma. However …
mediate objective cancer regression in human patients with metastatic melanoma. However …
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
Mammalian microRNAs are emerging as key regulators of the development and function of
the immune system. Here, we report a strong but transient induction of miR-155 in mouse …
the immune system. Here, we report a strong but transient induction of miR-155 in mouse …
Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor
Infusions of antigen-specific T cells have yielded therapeutic responses in patients with
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …
pathogens and tumors. To broaden the clinical application of adoptive immunotherapy …
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
BD Brown, B Gentner, A Cantore, S Colleoni… - Nature …, 2007 - nature.com
We have shown previously that transgene expression can be suppressed in hematopoietic
cells using vectors that are responsive to microRNA (miRNA) regulation. Here we …
cells using vectors that are responsive to microRNA (miRNA) regulation. Here we …
MicroRNA-125b potentiates macrophage activation
AA Chaudhuri, AYL So, N Sinha… - The Journal of …, 2011 - journals.aai.org
Abstract MicroRNA (miR)-125b expression is modulated in macrophages in response to
stimulatory cues. In this study, we report a functional role of miR-125b in macrophages. We …
stimulatory cues. In this study, we report a functional role of miR-125b in macrophages. We …
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma
T Chodon, B Comin-Anduix, B Chmielowski… - Clinical Cancer …, 2014 - AACR
Purpose: It has been demonstrated that large numbers of tumor-specific T cells for adoptive
cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous …
cell transfer (ACT) can be manufactured by retroviral genetic engineering of autologous …
miR-146a controls the resolution of T cell responses in mice
T cell responses in mammals must be tightly regulated to both provide effective immune
protection and avoid inflammation-induced pathology. NF-κB activation is a key signaling …
protection and avoid inflammation-induced pathology. NF-κB activation is a key signaling …