The role of DNA methylation in placental development and its implications for preeclampsia

Y Meng, Y Meng, L Li, Y Li, J He… - Frontiers in Cell and …, 2024 - frontiersin.org
Preeclampsia (PE) is a prevalent and multifaceted pregnancy disorder, characterized by
high blood pressure, edema, proteinuria, and systemic organ dysfunction. It remains one of …

Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes

LA Eaves, CE Harrington, RC Fry - Current Environmental Health Reports, 2024 - Springer
Abstract Purpose of Review We summarize the recent literature investigating exposure to
four nonchemical stressors (financial stress, racism, psychosocial stress, and trauma) and …

Genetic factors in the etiology of preeclampsia/eclampsia

K Ward, RN Taylor - Chesley's hypertensive disorders in pregnancy, 2015 - Elsevier
Preeclampsia is a complex familial disorder, which likely involves multiple genes in multiple
biological pathways. Family reports, twin studies, segregation analyses, linkage analyses …

Disruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia

X Gong, W He, W Jin, H Ma, G Wang, J Li, Y Xiao… - Genome Biology, 2024 - Springer
Background Preeclampsia, one of the most lethal pregnancy-related diseases, is associated
with the disruption of uterine spiral artery remodeling during placentation. However, the …

Methylome profiling of cell-free DNA during the early life course in (un) complicated pregnancies using MeD-seq: Protocol for a cohort study embedded in the …

MM van Vliet, S Schoenmakers, RG Boers… - PloS one, 2025 - journals.plos.org
Introduction Placental DNA methylation differences have been associated with timing in
gestation and pregnancy complications. Maternal cell-free DNA (cfDNA) partly originates …

Comprehensive analyses of DNA methylation of the TIMP3 promoter in placentas from early-onset and late-onset preeclampsia

JO Cruz, IMCA Conceição, VC Sandrim, MR Luizon - Placenta, 2022 - Elsevier
Preeclampsia (PE) is classified into late-onset (LOPE) or early-onset (EOPE) according to
gestational age of onset (≥ 34 or< 34 weeks, respectively), and into preterm and term …

Genome‐wide methylation profiling of maternal cell‐free DNA using methylated DNA sequencing (MeD‐seq) indicates a placental and immune‐cell signature

MM van Vliet, RG Boers, JB Boers… - European Journal of …, 2024 - Wiley Online Library
Background Placental‐originated cell‐free DNA (cfDNA) provides unique opportunities to
study (epi) genetic placental programming remotely, but studies investigating the cfDNA …

Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre‐eclampsia

AC Palei, JO Cruz, JL Chaguri… - … of Gynecology & …, 2023 - Wiley Online Library
Objective To assess and compare circulating tissue inhibitor of metalloproteinase 3 (TIMP‐
3) concentrations between women with pre‐eclampsia and healthy pregnant women. We …

Whole genome bisulfite sequencing of serum extracellular vesicle DNA Identifies alterations in mitochondrial DNA methylation in early onset preeclampsia

U Shinde, K Khambata, S Raut, A Rao, V Bansal… - Clinica Chimica …, 2025 - Elsevier
Early-onset preeclampsia (EOPE) is a serious pregnancy complication. Understanding its
underlying mechanisms could lead to improved diagnosis and management. Genome-wide …

Evidence of under‐reporting of early‐onset preeclampsia using register data

JF Simard, M Rossides, AK Wikström… - Paediatric and …, 2021 - Wiley Online Library
Background Early‐onset preeclampsia, traditionally defined as presenting before 34
gestational weeks, is associated with even higher risks of perinatal death, placental …