Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg
effect, thereby presenting a potential therapeutic target in autoimmune disease. Dimethyl …

Drug repurposing is promoted as a cost-and time-effective mechanism for providing new
medicines. Often, however, there is insufficient consideration by academic researchers of …

In the past 20 years the treatment scenario of multiple sclerosis has radically changed. The
increasing availability of effective disease-modifying therapies has shifted the aim of …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates
hundreds of antioxidant genes, and is activated in response to oxidative stress. Given that …