International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …
and various drugs in development. Their diversity of structure and function reflects the …
Serotonin receptors involved in antidepressant effects
F Artigas - Pharmacology & therapeutics, 2013 - Elsevier
The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the
pathophysiology and treatment of major depression since the serendipitous discovery of …
pathophysiology and treatment of major depression since the serendipitous discovery of …
Mechanism of action of trazodone: a multifunctional drug
SM Stahl - CNS spectrums, 2009 - cambridge.org
Multifunctional drugs are those with more than one therapeutic mechanism. Trazodone is a
multifunctional drug with dose-dependent pharmacologic actions. That is, it has hypnotic …
multifunctional drug with dose-dependent pharmacologic actions. That is, it has hypnotic …
5-HT receptors and the development of new antidepressants
G Ślifirski, M Król, J Turło - International journal of molecular sciences, 2021 - mdpi.com
Serotonin modulates several physiological and cognitive pathways throughout the human
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …
Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications
P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …
and dopamine (DA) interactions play a key role in normal and abnormal behavior …
5-HT2C receptors in psychiatric disorders: a review
HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-
transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post …
transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post …
Serotonin and Parkinson's disease: On movement, mood, and madness
SH Fox, R Chuang, JM Brotchie - Movement disorders: official …, 2009 - Wiley Online Library
An appreciation of the multiple roles that serotonin (5‐HT) may play in Parkinson's disease
(PD) has increased in recent years. Early pathological studies in PD demonstrated …
(PD) has increased in recent years. Early pathological studies in PD demonstrated …
New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders
G Di Giovanni, P De Deurwaerdère - Pharmacology & therapeutics, 2016 - Elsevier
Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …
Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies
V Di Matteo, G Di Giovanni, M Pierucci… - Progress in brain …, 2008 - Elsevier
In this review, the functional interactions between serotonin (5-HT) and dopamine (DA)
neuronal systems are discussed with the focus on microdialysis studies in the rodent brain …
neuronal systems are discussed with the focus on microdialysis studies in the rodent brain …
Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus
Agomelatine is a novel antidepressant acting as a melatonergic receptor agonist and
serotonergic (5-HT 2C) receptor antagonist. In adult rats, chronic agomelatine treatment …
serotonergic (5-HT 2C) receptor antagonist. In adult rats, chronic agomelatine treatment …