The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

There is a pressing need to capture and track subtle cognitive change at the preclinical
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …

In Alzheimer's disease, post-mortem studies have shown that the first cortical site where
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …

There is an increasing role for biological markers (biomarkers) in the understanding and
diagnosis of neurodegenerative disorders. The application of imaging biomarkers …

Importance Dual decline in gait speed and cognition has been found to be associated with
increased dementia risk in previous studies. However, it is unclear if risks are conferred by a …

Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC)
in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve …

Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial
temporal lobe. However, there is evidence that, independently of Aβ, age-related tau …

Recent research has highlighted a role for the hippocampus and a Posterior Medial cortical
network in signaling event boundaries. However, little is known about whether or how these …

In early Alzheimer's disease (AD) β-amyloid (Aβ) deposits throughout association cortex and
tau appears in the entorhinal cortex (EC). Why these initially appear in disparate locations is …