Update on burning mouth syndrome: overview and patient management

A Scala, L Checchi, M Montevecchi… - Critical Reviews in …, 2003 - journals.sagepub.com
Burning Mouth Syndrome (BMS) is a chronic pain syndrome that mainly affects middle-
aged/old women with hormonal changes or psychological disorders. This condition is …

[HTML][HTML] Thiol homeostasis and supplements in physical exercise

CK Sen, L Packer - The American journal of clinical nutrition, 2000 - Elsevier
Thiols are a class of organic sulfur derivatives (mercaptans) characterized by the presence
of sulfhydryl residues. In biological systems, thiols have numerous functions, including a …

Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions

RN Perham - Annual review of biochemistry, 2000 - annualreviews.org
▪ Abstract Multistep chemical reactions are increasingly seen as important in a growing
number of complex biotransformations. Covalently attached prosthetic groups or swinging …

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

B Sameem, M Saeedi, M Mahdavi, A Shafiee - European journal of …, 2017 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurological disorder among elderly people and
combinatorial factors such as genetic, lifestyle, and environmental are involved in onset and …

Oxidative stress in Alzheimer's disease: are we connecting the dots? Miniperspective

M Rosini, E Simoni, A Milelli, A Minarini… - Journal of medicinal …, 2014 - ACS Publications
Redox impairment is a prominent feature of Alzheimer's disease (AD). It has led to the
“oxidative stress hypothesis”, which proposes antioxidants as beneficial therapeutic tools in …

Molecular basis of vitamin E action: tocotrienol potently inhibits glutamate-induced pp60c-Src kinase activation and death of HT4 neuronal cells

CK Sen, S Khanna, S Roy, L Packer - Journal of Biological Chemistry, 2000 - ASBMB
HT4 hippocampal neuronal cells were studied to compare the efficacy of tocopherols and
tocotrienol to protect against glutamate-induced death. Tocotrienols were more effective …

The effects and mechanisms of mitochondrial nutrient α-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview

J Liu - Neurochemical research, 2008 - Springer
We have identified a group of nutrients that can directly or indirectly protect mitochondria
from oxidative damage and improve mitochondrial function and named them “mitochondrial …

Rational approach to discover multipotent anti-Alzheimer drugs

M Rosini, V Andrisano, M Bartolini… - Journal of medicinal …, 2005 - ACS Publications
The coupling of two different pharmacophores, each endowed with different biological
properties, afforded the hybrid compound lipocrine (7), whose biological profile was …

Burning mouth syndrome (BMS): double blind controlled study of alpha‐lipoic acid (thioctic acid) therapy

F Femiano, C Scully - Journal of oral pathology & medicine, 2002 - Wiley Online Library
Background: Burning mouth syndrome (BMS) has features of a neuropathy and could be
related to the production of the toxic free radicals that are released in stress situations. Alpha …

Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors

A Castro, A Martinez - Current pharmaceutical design, 2006 - ingentaconnect.com
Although the hallmarks of neurodegeneration in Alzheimer's brains are well known, one of
the current difficulties is related to the lack of solid evidence about the ultimate factors that …