The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …

Diabetes mellitus (DM) has become a vital societal problem as epidemiological studies
demonstrate the increasing incidence of type 1 and type 2 diabetes. Lesions observed in the …

Angiogenesis is required for normal development and occurs as a pathological step in a
variety of disease settings, such as cancer, ocular diseases, and ischemia. Recent studies …

Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases,
diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases …

Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-
threatening condition, is one of the most common diabetes-specific complications. Diabetic …

Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus and
is characterized by degeneration of retinal neurons and neoangiogenesis, causing a severe …

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …

Diabetic retinopathy (DR) is a frequent complication of diabetes mellitus, and a common
cause of vision impairment and blindness in these patients, yet many aspects of its …