Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising
approach for cancer therapy with an expectation of no significant side effects. In the human …

Links between T cell clonotypes, as defined by T cell receptor (TCR) sequences, and
phenotype, as reflected in gene expression (GEX) profiles, surface protein expression and …

INTRODUCTION The adaptive immune system has evolved to mount different types of
responses that are matched to the type of invading pathogen. For CD4+ T cells, this is …

Antigen discovery technologies have largely focused on major histocompatibility complex
(MHC) class I-restricted human T cell receptors (TCRs), leaving methods for MHC class II …

T cells acquire a regulatory phenotype when their T cell antigen receptors (TCRs)
experience an intermediate-to high-affinity interaction with a self-peptide presented via the …

Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment.
We identify two MBC subsets in peripheral blood, CD27 dull and CD27 bright MBCs, whose …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that is estimated to
affect 35 million people worldwide and is characterized by lymphocytic infiltration, elevated …

Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune
disease risk. HLA risk alleles may influence thymic selection to increase the frequency of T …

The mammalian gastrointestinal tract can harbor both beneficial commensal bacteria
important for host health, but also pathogenic bacteria capable of intestinal damage. It is …