Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …

Many cellular Ca 2+-dependent signaling cascades utilize calmodulin (CaM) as the
intracellular Ca 2+ receptor. Ca 2+/CaM binds and activates a plethora of enzymes …

Background and Aims NAFLD represents an increasing health problem in association with
obesity and diabetes with no effective pharmacotherapies. Growing evidence suggests that …

Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …

Abstract Glycogen Synthase Kinase-3 (GSK3) was originally reported as a key enzyme of
glucose homeostasis through regulation of the rate of glycogen synthesis. It has …

The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …

Current pharmacological treatments for bipolar disorder are inadequate and based on
serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and …

Homeostasis of neural firing properties is important in stabilizing neuronal circuitry, but how
such plasticity might depend on alternative splicing is not known. Here we report that chronic …

Scope The prevalence of type 2 diabetes mellitus (T2DM) is increasing yearly worldwide.
Glycemic control is the basis for the treatment of T2DM, as it can prevent the progress of …

Objective Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of
diabetic patients leading to significant morbidity. There is impaired neurotrophic growth …