C Saraiva, C Praça, R Ferreira, T Santos… - Journal of controlled …, 2016 - Elsevier
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain homeostasis as well as ion …
Parkinson's disease causes a characteristic combination of motor symptoms due to progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars …
Advances in molecular and structural and functional neuroimaging are rapidly expanding the complexity of neurobiological understanding of Parkinson's disease (PD). This review …
Parkinson's disease (PD) is typically well recognized by its characteristic motor symptoms (eg, bradykinesia, rigidity, and tremor). The cognitive symptoms of PD are increasingly being …
Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory …
Central nervous system disorders, especially neurodegenerative diseases, are a public health priority and demand a strong scientific response. Various therapy procedures have …
Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several …
G Zhu, J Li, L He, X Wang… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Mild cognitive deficit in early P arkinson's disease (PD) has been widely studied. Here we have examined the effects of memantine in preventing memory …
M Poletti, U Bonuccelli - Therapeutic advances in …, 2013 - journals.sagepub.com
The spatiotemporal progression of dopamine depletion in Parkinson's disease (PD) provides a special model for assessing dopaminergic effects on neural systems with …