The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …

The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …

Nicotinamide adenine dinucleotide (NAD), a cofactor for hundreds of metabolic reactions in
all cell types, plays an essential role in metabolism, DNA repair, and aging. However, how …

In the past years, several lines of evidence have shown that cell cycle regulatory proteins
also can modulate metabolic processes. The transcription factor E2F1 is a central player …

Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the
small and large intestine of patients. Symptoms can be severe and lead to the interruption of …

Adult mammalian cardiomyocytes (CM) are postmitotic, differentiated cells that cannot re-
enter the cell cycle after any appreciable injury. Therefore, understanding the factors …

Sex-determining region Y-related high-mobility-group box transcription factor 11 (SOX11) is
an essential member of the SOX transcription factors and has been highlighted as an …

Gastric cancer is the most common malignant tumor in the digestive tract, with very high
morbidity and mortality in developing countries. The pathogenesis of gastric cancer is a …

Cadmium (Cd) is a toxic heavy metal and one of carcinogens that cause lung cancer.
However, the exact mechanism of Cd carcinogenesis remains unclear. To investigate the …

Gene autorepression is widely present in nature and is also employed in synthetic biology,
partly to reduce gene expression noise in cells. Optogenetic systems have recently been …