Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Cooling can reduce primary injury and prevent secondary injury to the brain after insults in
certain clinical settings and in animal models of brain insult. The mechanisms that underlie …

Objectives N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox
modulatory compound currently in trials for many neurological and psychiatric disorders …

Many therapies have shown promise in preclinical stroke studies, but few benefit patients. A
greater understanding of stroke pathophysiology is needed to successfully develop …

AIMS: Intracerebral hemorrhage is one of the most devastating subtypes of stroke, leaving
survivors with severe neurological deficits. Disruption of the blood brain barrier (BBB) …

Background and Purpose—The prognosis of spontaneous intracerebral hemorrhage (sICH)
is poor because of the mass effect arising from the hematoma and the associated peri …

In this paper, we review current knowledge on blood-brain barrier (BBB) dysfunction
following intracerebral hemorrhage (ICH). BBB disruption is a hallmark of ICH-induced brain …

Background: Intracerebral hemorrhage (ICH) accounts for up to 15% of all strokes and is
characterized by high rates of mortality and morbidity. The post-ICH brain injury can be …

Intracerebral hemorrhage (ICH) results from rupture of a blood vessel in the brain. After ICH,
the blood–brain barrier (BBB) surrounding the hematoma is disrupted, leading to cerebral …

High intracranial pressure (ICP) can impede cerebral blood flow resulting in secondary
injury or death following severe stroke. Compensatory mechanisms include reduced …