Aflatoxin B1 and M1: Biological properties and their involvement in cancer development

S Marchese, A Polo, A Ariano, S Velotto, S Costantini… - Toxins, 2018 - mdpi.com
Aflatoxins are fungal metabolites found in feeds and foods. When the ruminants eat
feedstuffs containing Aflatoxin B1 (AFB1), this toxin is metabolized and Aflatoxin M1 (AFM1) …

Aflatoxin B1: Metabolism, toxicology, and its involvement in oxidative stress and cancer development

W Cao, P Yu, KP Yang, D Cao - Toxicology Mechanisms and …, 2022 - Taylor & Francis
Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi, which are
widely distributed in nature. Aflatoxin B1 (AFB1) is the most toxic of these compounds and its …

Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents

J Deng, L Zhao, NY Zhang, NA Karrow… - … research/reviews in …, 2018 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) widely contaminates staple food and feed crops and is well-
known as the most potent natural hepatocarcinogen in humans and domesticated animals …

Research progress in toxicological effects and mechanism of aflatoxin B1 toxin

C Li, X Liu, J Wu, X Ji, Q Xu - PeerJ, 2022 - peerj.com
Fungal contamination of animal feed can severely affect the health of farm animals, and
result in considerable economic losses. Certain filamentous fungi or molds produce toxic …

Aflatoxin B1-induced epigenetic alterations: An overview

Y Dai, K Huang, B Zhang, L Zhu, W Xu - Food and Chemical Toxicology, 2017 - Elsevier
Abstract Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food
commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has …

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

D Li, WH Tolleson, D Yu, S Chen, L Guo… - … Science and Health …, 2019 - Taylor & Francis
Environmental exposures to hazardous chemicals are associated with a variety of human
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …

Noncoding RNAs: the shot callers in tumor immune escape

L Liu, Q Wang, Z Qiu, Y Kang, J Liu, S Ning… - Signal transduction and …, 2020 - nature.com
Immunotherapy, designed to exploit the functions of the host immune system against tumors,
has shown considerable potential against several malignancies. However, the utility of …

Role of epigenetics in mycotoxin toxicity: A review

L Li, Z He, Y Shi, H Sun, B Yuan, J Cai, J Chen… - Environmental …, 2023 - Elsevier
Mycotoxins can induce cell cycle disorders, cell proliferation, oxidative stress, and apoptosis
through pathways such as those associated with MAPK, JAK2/STAT3, and Bcl-w/caspase-3 …

Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells via P53 signaling

C Guo, J Wang, M Yang, Y Li, S Cui, X Zhou, Y Li… - …, 2017 - Taylor & Francis
Rapid development and deployment of engineered nanomaterials, such as amorphous
silica nanoparticles (SiNPs) in various commercial and biomedical applications have raised …

Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation

F Xu, K Yu, H Yu, P Wang, M Song, C Xiu… - Journal of Functional …, 2017 - Elsevier
To evaluate the chemoprotective effect and mechanism of lycopene (LYC) on aflatoxin B 1
(AFB 1)-induced liver injury, forty-eight male mice were randomly allocated and treated with …